Direct Reductive Amination of
Aldehydes and Ketones Using
Phenylsilane: Catalysis by Dibutyltin
Dichloride
Richard Apodaca* andWei Xiao
The R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121
rapodaca@prius.jnj.com
Received April 5, 2001
Abstract:
A procedure for direct reductive amination of aldehydes and ketones was developed which uses phenylsilane as a stoichiometric reductant
and dibutyltin dichloride as a catalyst. Suitable amines included anilines and dialkylamines but not monoalkylamines.
