Use of Cerny Epoxides for the
Accelerated Synthesis of
Glycosaminoglycans
Sabine Arndt andLinda C. Hsieh-Wilson*
Division of Chemistry and Chemical Engineering, California Institute of Technology,
Pasadena, California 91125
lhw@caltech.edu
Received August 26, 2003
Abstract:
1,6:2,3-Dianhydrohexopyranoses (Cerny epoxides) are versatile intermediates for the synthesis of glycosaminoglycans. Complex heparan and
chondroitin sulfate disaccharide synthons can be assembled from a single common precursor in a short sequence of steps.
