A Metallocene-Pyrrolidinopyridine
Nucleophilic Catalyst for Asymmetric
Synthesis
Huy V. Nguyen,David C. D. Butler, andChristopher J. Richards*
School of Biological and Chemical Sciences, Queen Mary, University of London,
Mile End Road E1 4NS, U.K.
c.j.richards@qmul.ac.uk
Received December 16, 2005
Abstract:
A highly active chiral 4-aminopyridine nucleophilic catalyst, available in three steps from (S,S)-hexane-2,5-diol, was applied to the asymmetric
Steglich rearrangement of O-aceylated azlactones (1 mol % loading, up to 76% ee).
