Synthetic Studies toward the
Bryostatins: A Substrate-Controlled
Approach to the A-Ring
Gary E. Keck,*Dennie S. Welch, andPaige K. Vivian
Department of Chemistry, University of Utah, 315 South 1400 East RM 2020,
Salt Lake City, Utah 84112-0850
keck@chemistry.utah.edu
Received May 12, 2006
Abstract:
The synthesis of a C1-C13 A-ring subunit of bryostatin 1 is detailed. The key features of the approach include the convergent fragment
assembly with a highly stereoselective construction of the C7-C8 bond indicated above.
