Synthesis and PKC Binding of a New
Class of A-Ring Diversifiable Bryostatin
Analogues Utilizing a Double
Asymmetric Hydrogenation and
Cross-Coupling Strategy
Paul A. Wender* andJoshua C. Horan
Department of Chemistry, Stanford University, Stanford, California 94305-5080, and
Department of Molecular Pharmacology, Stanford University School of Medicine,
Stanford University, Stanford, California 94305-5080
wenderp@stanford.edu
Received July 23, 2006
Abstract:
The design, asymmetric synthesis, and biological evaluation of a new class of bryostatin analogues based on a pseudosymmetric spacer
domain are described. An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues
all exhibit potent, nanomolar affinity to PKC.
and
