Web Release Date: March 30,
Origins of the High 14-Helix Propensity
of Cyclohexyl-Rigidified Residues in
-Peptides
and
Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, and Department of Chemistry and Center for Chemical Methodologies and Library Development, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Received February 28, 2007
| Abstract: |
 |
-Peptides containing residues derived from trans-2-aminocyclohexanecarboxylic acid (ACHC) display high population of 14-helical secondary
structure in aqueous solution. We show that hydrophobic interactions between cyclohexyl rings are not responsible for this conformation-promoting effect, and that polar groups may be attached to the cyclohexyl ring without diminishing the effect.
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