Skeletal Diversity through Radical
Cyclization of Tetrahydropyridine
Scaffolds
Sivaraman Dandapani,Mihai Duduta,James S. Panek,* andJohn A. Porco, Jr.*
Department of Chemistry and Center for Chemical Methodology and Library
Development, Boston University, 590 Commonwealth Avenue,
Boston, Massachusetts 02215
panek@bu.edu; porco@bu.edu
Received July 19, 2007
Abstract:
Suitably functionalized tetrahydropyridines (methyl pipecolates) have been used as conformationally biased templates for radical cyclizations
to access benzoisoquinuclidines and linearly fused indenopiperidines. Variation of skeletal types is determined by location of a radical-initiating element.
