Divergent Approach for Synthesis and
Terminal Modifications of Dendritic
Polyphenylazomethines
Kensaku Takanashi andKimihisa Yamamoto*
Department of Chemistry, Faculty of Science & Technology, Keio University,
Yokohama 223-8522, Japan
yamamoto@chem.keio.ac.jp
Received August 8, 2007
Abstract:
In the past, dendritic polyphenylazomethines (DPA) have been synthesized via the convergent method. However, the convergent method has
problems such as difficult terminal-group modifications and an increased number of steps. Therefore, we synthesized the terminal-protected
DPA to construct the dendritic structure via the divergent method. The combination of the convergent method and the divergent method
easily achieved the rapid synthesis of a higher generation dendrimer. Furthermore, we succeeded in the synthesis of the water-soluble PEG-DPA via the divergent method using the ester-DPA.
