Preparation of Alkylidene Indane and
Related Scaffolds and Their Further
Elaboration to Novel Chemotypes
Sarathy Kesavan,James S. Panek,* andJohn A. Porco, Jr.*
Department of Chemistry and Center for Chemical Methodology and Library
Development (CMLD-BU), Boston University, 590 Commonwealth Avenue,
Boston, Massachusetts 02215
porco@bu.edu; panek@bu.edu
Received September 29, 2007
Abstract:
Alkylidene indane and ring-expanded scaffolds have been prepared using an enantioselective crotylation/Heck cyclization sequence. Further
diversification using consecutive cyclopropanation-Cope rearrangement affords novel chemotypes including spiroindane frameworks.
