Dendrimeric Molecular Transporters:
Synthesis and Evaluation of Tunable
Polyguanidino Dendrimers That
Facilitate Cellular Uptake
Paul A. Wender,*Erik Kreider,Erin T. Pelkey,Jonathan Rothbard,* and
Christopher L. VanDeusen*
Department of Chemistry and Department of Molecular Pharmacology,
Stanford University, Stanford, California 94305-5080, and Cellgate, Inc.,
552 Del Rey Avenue, Sunnyvale, California 94086
wenderp@stanford.edu
Received June 27, 2005
Revised September 14, 2005
Abstract:
Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized
in an efficient, scalable sequence using a trifluoroacetamide protecting group-perguanidinylation strategy. While the dendrimers varied
significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.
