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Article

Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective On-Line Solid-Phase Extraction of 4-Nitrophenol from Environmental Water

Núria Masqué,*^† Rosa M. Marcé,^† Francesc Borrull,^† Peter A. G. Cormack,^‡ and David C. Sherrington^‡

Departament de Qumica Analtica i Qumica Orgnica, Universitat Rovira i Virgili, Imperial Tarraco, 1, 43005 Tarragona, Spain, and Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, U.K.

Anal. Chem., 2000, 72 (17), pp 4122–4126

DOI: 10.1021/ac0000628

Publication Date (Web): July 25, 2000

Corresponding author: (fax) +34 977 559563; (e-mail) masque@ quimica.urv.es.

†

Universitat Rovira i Virgili.

‡

University of Strathclyde.

Abstract

A molecularly imprinted polymer (MIP) able to bind 4-nitrophenol (4-NP) was prepared using noncovalent molecular imprinting methods and evaluated as a selective sorbent in molecularly imprinted solid-phase extraction (MISPE) on-line coupled to a reversed-phase HPLC. It has been shown that the conditions chosen for washing the MIP and for eluting the analyte in the MISPE process are extremely important for ensuring good selectivity and recovery. River water samples, spiked with the 11 Environmental Protection Agency phenolic compounds at microgram per liter levels, were preconcentrated on-line using this MIP, and 4-NP was selectively extracted. The humic acid interference was simultaneously reduced considerably. The MIP was also compared with a commercially available highly cross-linked polymer (LiChrolut EN) and the former yielded cleaner extracts.

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