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Atmospheric Pressure Ionization in a Miniature Mass Spectrometer
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Section:Abstract
A miniature cylindrical ion trap mass spectrometer featuring an atmospheric pressure interface allowing atmospheric pressure chemical ionization and electrospray ionization is described together with its analytical performance characteristics. The vacuum system, ion optics, mass analyzer, control electronics system, and detection system have all been designed and built in-house. The design is based upon a three-stage, differentially pumped vacuum system with the instrument capable of being interfaced to many types of atmospheric pressure ionization sources. Ions are transferred through home-built ion optics, and instrument control is achieved through custom-designed electronics and LabView control software. Corona discharge ionization and electrospray ionization sources are implemented and used to allow the analysis of both gaseous- and solution-phase samples during the characterization of the instrument. An upper mass/charge limit of 
450 Th with unit resolution was achieved using a 2.5-mm-internal radius cylindrical ion trap as the mass analyzer. The specificity of the instrument can be increased by employing the MS/MS capabilities of the ion trap and has been demonstrated for nitrobenzene. Limits of detection for the trace analysis in air of the chemical warfare agent simulant methyl salicylate (1.24 ppb) and for nitrobenzene (629 pptr) are achieved. The dynamic range of the instrument is currently limited to 2 orders of magnitude by saturation of the detection electronics. Isolation and collision-induced dissociation efficiencies in MS/MS experiments both greater than 50% are reported. Electrospray/nanospray data are presented on solutions including 100 μΜ (d,l)-arginine, 10 μM (−)-ephedrine, and 10 μM lomefloxacin.
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This article has been cited by 8 ACS Journal articles (5 most recent appear below).
Sampling Wand for an Ion Trap Mass Spectrometer
Keyong Hou, Wei Xu, Jian Xu, R. Graham Cooks, and Zheng OuyangAnalytical Chemistry2011 83 (5), 1857-1861Sampling Wand for an Ion Trap Mass Spectrometer
Keyong Hou, Wei Xu, Jian Xu, R. Graham Cooks, and Zheng OuyangAnalytical Chemistry2011 83 (5), 1857-1861A new sampling wand concept for ion trap mass spectrometers equipped with discontinuous atmospheric pressure interfaces (DAPI) has been implemented. The ion trap/DAPI combination facilitates the operation of miniature mass spectrometers equipped with ...
Direct Analysis of Volatile Methylsiloxanes in Gaseous Matrixes Using Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry
Koffi Badjagbo, Alexandra Furtos, Mehran Alaee, Serge Moore and Sébastien SauvéAnalytical Chemistry2009 81 (17), 7288-7293Direct Analysis of Volatile Methylsiloxanes in Gaseous Matrixes Using Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry
Koffi Badjagbo, Alexandra Furtos, Mehran Alaee, Serge Moore and Sébastien SauvéAnalytical Chemistry2009 81 (17), 7288-7293Atmospheric pressure chemical ionization-tandem mass spectrometry (APCI-MS/MS) was applied for the first time to the direct analysis of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in gaseous matrixes without extraction or prior ...
Design and Characterization of a Multisource Hand-Held Tandem Mass Spectrometer
Liang Gao, Andy Sugiarto, Jason D. Harper, R. Graham Cooks and Zheng OuyangAnalytical Chemistry2008 80 (19), 7198-7205Design and Characterization of a Multisource Hand-Held Tandem Mass Spectrometer
Liang Gao, Andy Sugiarto, Jason D. Harper, R. Graham Cooks and Zheng OuyangAnalytical Chemistry2008 80 (19), 7198-7205A wireless-controlled miniature rectilinear ion trap mass spectrometer system, total weight with batteries 5.0 kg, consuming less than 35 W of power, and having dimensions of 22 cm in length by 12 cm in width by 18 cm in height, is characterized. The ...
Breaking the Pumping Speed Barrier in Mass Spectrometry: Discontinuous Atmospheric Pressure Interface
Liang Gao, R. Graham Cooks and Zheng OuyangAnalytical Chemistry2008 80 (11), 4026-4032Breaking the Pumping Speed Barrier in Mass Spectrometry: Discontinuous Atmospheric Pressure Interface
Liang Gao, R. Graham Cooks and Zheng OuyangAnalytical Chemistry2008 80 (11), 4026-4032The performance of mass spectrometers with limited pumping capacity is shown to be improved through use of a discontinuous atmospheric pressure interface (DAPI). A proof-of-concept DAPI interface was designed and characterized using a miniature ...
Monitoring of Toxic Compounds in Air Using a Handheld Rectilinear Ion Trap Mass Spectrometer
Adam Keil, Heriberto Hernandez-Soto, Robert J. Noll, Miriam Fico, Liang Gao, Zheng Ouyang, and R. Graham CooksAnalytical Chemistry2008 80 (3), 734-741Monitoring of Toxic Compounds in Air Using a Handheld Rectilinear Ion Trap Mass Spectrometer
Adam Keil, Heriberto Hernandez-Soto, Robert J. Noll, Miriam Fico, Liang Gao, Zheng Ouyang, and R. Graham CooksAnalytical Chemistry2008 80 (3), 734-741A miniature, handheld mass spectrometer, based on the rectilinear ion trap mass analyzer, has been applied to air monitoring for traces of toxic compounds. The instrument is battery-operated, hand-portable, and rugged. We anticipate its use in public ...
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History
- Published In Issue May 01, 2005
- Received for review December 12, 2004. Accepted March 1, 2005.
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