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Multiplexed Rectilinear Ion Trap Mass Spectrometer for High-Throughput Analysis

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Amy M. Tabert, Michael P. Goodwin, Jason S. Duncan, Charles D. Fico, and R. Graham Cooks*

Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084

Anal. Chem., 2006, 78 (14), pp 4830–4838

DOI: 10.1021/ac060149e

Publication Date (Web): May 28, 2006

Section:

Organic Analytical Chemistry

Abstract

A multichannel mass spectrometer based on the rectilinear ion trap (RIT) analyzer was designed and constructed for simultaneous high-throughput analysis of multiple samples. The instrument features four parallel ion source/mass analyzer/detector channels assembled in a single vacuum chamber and operated using a common set of control electronics, including a single rf amplifier and transformer coil. This multiplexed RIT mass spectrometer employs an array of four millimeter-sized ion traps (x_o = 5.0 mm and y_o = 4.0 mm, where x_o and y_o are the half-distances in the x and y dimensions, respectively). Mass spectra are acquired from four different samples simultaneously. The available mass/charge range is m/z 15−510 with excellent linearity of the mass calibration (R² = 0.999 999). The peak width is less than 0.3 mass/charge units at m/z 146, corresponding to a resolution of 500. Simultaneous MS/MS of ions due to four compounds (3-fluoroanisole, 4-fluoroanisole, 2-fluorobenzyl alcohol, 2,6-dimethylcyclohexanone) with the same nominal molecular radical cation but distinctive fragmentation patterns was demonstrated. Isolation and fragmentation efficiencies were 25 and 75%, respectively, measured in the typical case of the molecular radical cation of acetophenone. Preacquisition differential data were obtained by real-time subtraction of the ion signals from two channels of the multiplexed mass spectrometer. The differential experiment presented offers proof of principle of comparative mass spectra in high-throughput screening applications while reducing data storage requirements.

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This article has been cited by 4 ACS Journal articles (4 most recent appear below).

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Multiplexed Four-Channel Rectilinear Ion Trap Mass Spectrometer
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  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Ion Soft Landing Using a Rectilinear Ion Trap Mass Spectrometer
Wen-Ping Peng, Michael P. Goodwin, Zongxiu Nie, Michael Volný, Zheng Ouyang and R. Graham Cooks
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