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Small Correspondence

Comments on Total Platinum Concentration and Platinum Oxidation States in Body Fluids, Tissue, and Explants from Women Exposed to Silicone and Saline Breast Implants by IC−ICPMS

Michael A. Brook*^†

Department of Chemistry, McMaster University, 1280 Main Street W., Hamilton, ON, Canada

Anal. Chem., 2006, 78 (15), pp 5609–5611

DOI: 10.1021/ac060779g

Publication Date (Web): July 31, 2006

Fax: +1 (905) 522 2509; Tel: +1 (905) 525 9140 ext. 23483; E-mail: mabrook@mcmaster.ca.

†

The author provided information on the chemical nature of the platinum in silicone breast implants at the FDA panel hearing on breast implants April 2005 on behalf of Inamed Corporation. He was also a member of Health Canada regulatory advisory panels considering applications by Mentor Corporation and Inamed Corporation for new breast implant models in March and September 2005.

Abstract

The paper by Lykissa and Maharaj (Lykissa, E. D.; Maharaj, S. V. M. Anal. Chem. 2006, 78, 2925−2933) comes to two main conclusions: platinum is found at elevated levels in women who have received breast implants, and the platinum is present in unusual oxidation states. The authors make clear their view that these are very surprising and disturbing results, both because of the quantity of platinum found and the association between higher oxidation states of platinum and toxicity of various types (sensitization−contact dermatitis, carcinogencity, among others). However, the conclusions arrived at by the authors are unsupported by the Experimental Section of the paper and the data that are reported there, and contravene the well-established chemistry of platinum.

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