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Particle Dispersion and Separation Resolution of Pinched Flow Fractionation

Abhishek Jain and Jonathan D. Posner*

Department of Mechanical and Aerospace Engineering, Arizona State University, Tempe, Arizona 85287

Anal. Chem., 2008, 80 (5), pp 1641–1648

DOI: 10.1021/ac0713813

Publication Date (Web): January 26, 2008

Abstract

This paper investigates a hydrodynamic particle separation technique that employs pinching of particles to a narrow microchannel. The particles are subject to a sudden expansion which results in a size-based particle separation transverse to the flow direction. The separation resolution and particle dispersion are measured using epifluorescence microscopy. The resolution and dispersion are predicted using a compact theoretical model. Devices are fabricated using conventional soft lithography of polydimethylsiloxane. The results show that the separation resolution is a function of the microchannel aspect ratio, particle size difference, and the microchannel sidewall roughness. A separation resolution as large as 3.8 is obtained in this work. This work shows that particles with diameters on the order of the sidewall roughness cannot be separated using pinched flow fractionation.

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History

Published In Issue March 01, 2008
Received for review June 29, 2007. Accepted November 30, 2007.

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Particle Dispersion and Separation Resolution of Pinched Flow Fractionation