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Giant Magnetoresistance Sensors. 1. Internally Calibrated Readout of Scanned Magnetic Arrays
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Hi-Res PDFPresent address: Department of Chemistry, Northern Kentucky University, Highland Heights, KY 41099.
, ‡Present address: Diagnostic Biosensors, LLC, 1712 Brook Ave. SE, Minneapolis, MN 55414.
Section:Abstract
This paper describes efforts aimed at setting the stage for the application of giant magnetoresistance sensor (GMRs) networks as readers for quantification of biolytes selectively captured and then labeled with superparamagnetic particles on a scanned chip-scale array. The novelty and long-range goal of this research draws from the potential development of a card-swipe instrument through which an array of micrometer-sized, magnetically tagged addresses (i.e., a sample stick) can be interrogated in a manner analogous to a credit card reader. This work describes the construction and testing of a first-generation instrument that uses a GMR sensor network to read the response of a “simulated” sample stick. The glass sample stick is composed of 20-nm-thick films of permalloy that have square or rectangular lateral footprints of up to a few hundred micrometers. Experiments were carried out to gain a fundamental understanding of the dependence of the GMR response on the separation between, and planarity of, the scanned sample stick and sensor. Results showed that the complex interplay between these experimentally controllable variables strongly affect the shape and magnitude of the observed signal and, ultimately, the limit of detection. This study also assessed the merits of using on-sample standards as internal references as a facile means to account for small variations in the gap between the sample stick and sensor. These findings were then analyzed to determine various analytical figures of merit (e.g., limit of detection in terms of the amount of magnetizable material on each address) for this readout strategy. An in-depth description of the first-generation test equipment is presented, along with a brief discussion of the potential widespread applicability of the concept.
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This article has been cited by 3 ACS Journal articles (3 most recent appear below).
A Three-Layer Competition-Based Giant Magnetoresistive Assay for Direct Quantification of Endoglin from Human Urine
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Nanomagnetic Competition Assay for Low-Abundance Protein Biomarker Quantification in Unprocessed Human Sera
Yuanpeng Li, Balasubramanian Srinivasan, Ying Jing, Xiaofeng Yao, Marie A. Hugger, Jian-Ping Wang and Chengguo XingJournal of the American Chemical Society2010 132 (12), 4388-4392Nanomagnetic Competition Assay for Low-Abundance Protein Biomarker Quantification in Unprocessed Human Sera
Yuanpeng Li, Balasubramanian Srinivasan, Ying Jing, Xiaofeng Yao, Marie A. Hugger, Jian-Ping Wang and Chengguo XingJournal of the American Chemical Society2010 132 (12), 4388-4392A novel giant magnetoresistive sensor and uniform high-magnetic-moment FeCo nanoparticles (12.8 nm)-based detecting platform with minimized detecting distance was developed for rapid biomolecule quantification from body fluids. Such a system demonstrates ...
Giant Magenetoresistive Sensors. 2. Detection of Biorecognition Events at Self-Referencing and Magnetically Tagged Arrays
Rachel L. Millen, John Nordling, Heather A. Bullen and Marc D. Porter, Mark Tondra, Michael C. GrangerAnalytical Chemistry2008 80 (21), 7940-7946Giant Magenetoresistive Sensors. 2. Detection of Biorecognition Events at Self-Referencing and Magnetically Tagged Arrays
Rachel L. Millen, John Nordling, Heather A. Bullen and Marc D. Porter, Mark Tondra, Michael C. GrangerAnalytical Chemistry2008 80 (21), 7940-7946Microfabricated devices formed from alternating layers of magnetic and nonmagnetic materials at combined thicknesses of a few hundred nanometers exhibit a phenomenon known as the giant magnetoresistance effect. Devices based on this effect are known as ...
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History
- Published In Issue November 01, 2008
- Article ASAPOctober 01, 2008
- Received: May 08, 2008
Accepted: August 09, 2008
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