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Quantitative ³⁵Cl Nuclear Quadrupole Resonance in Tablets of the Antidiabetic Medicine Diabinese

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Elizabeth Tate, Kaspar Althoefer, Jamie Barras, Michael D. Rowe and John A. S. Smith*

King’s College London, Department of Mechanical Engineering, Strand, London, WC2R 2LS, United Kingdom

Gareth E. S. Pearce

Merck, Sharp and Dohme, Hertford Road, Hoddesdon, Hertfordshire, EN11 9BU, United Kingdom

Stephen A. C. Wren

AstraZeneca, Silk Road Business Park, Charter Way, Macclesfield, Cheshire, SK10 2NA, United Kingdom

Anal. Chem., 2009, 81 (13), pp 5574–5576

DOI: 10.1021/ac900656e

Publication Date (Web): June 3, 2009

* To whom correspondence should be addressed. E-mail: John.Smith@kcl.ac.uk.

Abstract

Pulsed ³⁵Cl nuclear quadrupole resonance (NQR) experiments have been performed on 250-mg tablets of the antidiabetic medicine Diabinese to establish the conditions needed for noninvasive quantitative analysis of the medicine in standard bottles. One important condition is the generation of a uniform radio-frequency (RF) field over the sample, which has been achieved by two designs of sample coil: one of variable pitch, and the other a resonator that has been fabricated from a single turn of copper sheet with a longitudinal gap bridged by tuning capacitors. The results from blind tests show that the number of tablets in a bottle could be predicted to within ±3%.

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
Silvina Limandri, Claudia Visñovezky, Silvina C. Pérez, Clemar A. Schurrer, Alberto E. Wolfenson, Maribel Ferro, Silvia L. Cuffini, Joel Gonçalves de Souza, F. Armani Aguiar, and C. Masetto de Gaitani
Analytical Chemistry2011 83 (5), 1773-1776
- Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry
  Silvina Limandri, Claudia Visñovezky, Silvina C. Pérez, Clemar A. Schurrer, Alberto E. Wolfenson, Maribel Ferro, Silvia L. Cuffini, Joel Gonçalves de Souza, F. Armani Aguiar, and C. Masetto de Gaitani
  Analytical Chemistry2011 83 (5), 1773-1776
  Pharmaceuticals can exist in many solid forms, which can have different physical and chemical properties. These solid forms include polymorphs, solvates, amorphous, and hydrates. Particularly, hydration process can be quite common since pharmaceutical ...
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History

Published In Issue July 01, 2009
Article ASAPJune 03, 2009
Received: March 30, 2009
Accepted: May 12, 2009

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Technical Note

Quantitative ³⁵Cl Nuclear Quadrupole Resonance in Tablets of the Antidiabetic Medicine Diabinese

Abstract

Citing Articles

Nuclear Quadrupole Resonance: A Technique to Control Hydration Processes in the Pharmaceutical Industry