Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
- Zhong-Jian ChenZhong-Jian ChenHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Zhong-Jian Chen
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- Si-Cong YangSi-Cong YangHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Si-Cong Yang
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- Xue-Liang LiuXue-Liang LiuHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Xue-Liang Liu
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- Yuhao GaoYuhao GaoHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Yuhao Gao
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- Xiao DongXiao DongHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Xiao Dong
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- Xing LaiXing LaiHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Xing Lai
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- Mao-Hua ZhuMao-Hua ZhuHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Mao-Hua Zhu
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- Hai-Yi FengHai-Yi FengHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Hai-Yi Feng
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- Xin-Di ZhuXin-Di ZhuHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Xin-Di Zhu
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- Qin LuQin LuHongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Qin Lu
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- Mei ZhaoMei ZhaoDepartment of Pharmacy, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Road, Shanghai 201318, ChinaMore by Mei Zhao
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- Hong-Zhuan ChenHong-Zhuan ChenInstitute of Interdisciplinary Integrative Biomedical Research, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaMore by Hong-Zhuan Chen
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- Jonathan F. Lovell*Jonathan F. Lovell*Email: [email protected] (J.F.L.).Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, United StatesMore by Jonathan F. Lovell
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- Chao Fang*Chao Fang*Email: [email protected] (C.F.).Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMore by Chao Fang
Abstract
Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.
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