Medicinal Surface Modification of Silicon Nanowires: Impact on Calcification and Stromal Cell Proliferation

Ke Jiang†, Dongmei Fan†, Yamina Belabassi†, Giridhar Akkaraju‡, Jean-Luc Montchamp† and Jeffery L. Coffer*†
Department of Chemistry and Department of Biology, Texas Christian University, Fort Worth, Texas 76129
ACS Appl. Mater. Interfaces, 2009, 1 (2), pp 266–269
DOI: 10.1021/am800219r
Publication Date (Web): December 30, 2008
Copyright © 2008 American Chemical Society
†

Department of Chemistry.

,
‡

Department of Biology.

,
* To whom correspondence should be addressed. E-mail: j.coffer@tcu.edu.

Abstract

Abstract Image

Medicinal surface modification of silicon nanowires (SiNWs) with selected bisphosphonates, such as the known antiosteoporotic drug alendronate, is described. In terms of specific assays relevant to orthopedic applications, the impact of selected bisphosphonate attachment on acellular calcification in simulated plasma is reported. To further investigate biocompatibility, proliferation assays of these modified nanowires were carried out using an orthopedically relevant cell line: mesenchymal stem cells derived from mouse stroma. It is found that the identity of the bisphosphonate ligand strongly and sensitively impacts its resultant cytotoxicity.

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History

  • Published In Issue February 25, 2009
  • Article ASAPDecember 30, 2008
  • Received: December 5, 2008
    Accepted: December 19, 2008

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