Advances in the Catalytic, Asymmetric Synthesis of β-Lactams

Stefan France, Anthony Weatherwax, Andrew E. Taggi, and Thomas Lectka*
Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218
Acc. Chem. Res., 2004, 37 (8), pp 592–600
DOI: 10.1021/ar030055g
Publication Date (Web): May 11, 2004
Copyright © 2004 American Chemical Society

Stefan France obtained his B. S. in chemistry from Duke University in 2000 where he studied with Eric Toone. His graduate career began in the fall of 2000 when he joined the research group of Professor Tom Lectka. Stefan's Ph.D. research centers around new methodology for catalytic, asymmetric, and site-selective halogenations. Stefan currently holds fellowships sponsored by the Johns Hopkins University, UNCF, Merck, and Pfizer.

Anthony Weatherwax has been awarded several baccalaureate degrees from State University of New York (SUNY), Albany, Arizona, and Maryland. He joined the Lectka group in 2001 and is currently investigating methods for the asymmetric synthesis of β-lactams.

Andrew E. Taggi obtained his B.S. from Cornell University in 1998. His graduate research with Tom Lectka concerned the development of new methodology for the use of ketenes in catalytic, asymmetric synthesis for which he received an ACS DOC Fellowship, sponsored by Organic Reactions, Inc. A.T. is currently a postdoctoral associate with Professor Jerrold Meinwald (Cornell).

Tom Lectka is a native of Detroit who was graduated from Oberlin College in 1986. He obtained his Ph.D from Cornell University, where he worked in John McMurry's laboratory. After a Humboldt Fellowship to study at Heidelberg, he joined Dave Evans's laboratory at Harvard University as a postdoc. In 1994, he began at Johns Hopkins University, where he was promoted to Professor in 2002. His research interests broadly span problems in catalysis and mechanistic organic chemistry.

Biomolecules and Their Synthetic Analogs

Abstract

In this Account, we illustrate our contribution to the catalytic, asymmetric synthesis of β-lactams through a flexible [2 + 2] cycloaddition strategy. We also explore the scope of our methodology and comment on future directions.

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History

  • Published In Issue August 17, 2004
  • Received December 3, 2003

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