Synthesis of Various Glycopolymer Architectures via RAFT Polymerization:  From Block Copolymers to Stars

Julien Bernard,† Xiaojuan Hao, Thomas P. Davis, Christopher Barner-Kowollik, and Martina H. Stenzel*
Centre for Advanced Macromolecular Design (CAMD), School of Engineering and Industrial Chemistry, The University of New South Wales, Sydney NSW 2052 Australia
Biomacromolecules, 2006, 7 (1), pp 232–238
DOI: 10.1021/bm0506086
Publication Date (Web): December 13, 2005
Copyright © 2006 American Chemical Society
†

 Current address:  Laboratoire de Chimie Macromoléculaire, Université Paris 6, Paris, France.

,
*

 To whom correspondence should be addressed. Fax: + 61 2 9385−6250. E-mail:  camd@unsw.edu.au. Web site:  http:// www.camd.unsw.edu.au.

Abstract

Abstract Image

Well-defined linear poly(acryloyl glucosamine) (PAGA) exhibiting molar masses ranging from 3 to 120 K and low polydispersities have been prepared via reversible addition-fragmentation chain transfer polymerization (RAFT) in aqueous solution without recourse to protecting group chemistry. The livingness of the process was further demonstrated by successfully chain-extending one of these polymers with N-isopropylacrylamide affording narrow dispersed thermosensitive diblocks. This strategy of polymerization was finally extended to the preparation of glycopolymer stars from Z designed non-water-soluble trifunctional RAFT agent. After the growth of very short blocks of poly(hydroxyethyl acrylate) ( nbranch = 10), AGA was polymerized in aqueous solution in a controlled manner affording well-defined 3-arm glycopolymer stars.

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History

  • Published In Issue January 09, 2006
  • Received August 24, 2005
    Revised Manuscript Received October 24, 2005

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