Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

D. Matthew Eby*†, Karen E. Farrington‡ and Glenn R. Johnson*§
Universal Technology Corporation, Applied Research Associates, Inc., and Air Force Research Laboratory, Materials and Manufacturing Directorate, Microbiology and Applied Biochemistry, 139 Barnes Drive, Suite 2, Tyndall Air Force Base, Florida 32403
Biomacromolecules, 2008, 9 (9), pp 2487–2494
DOI: 10.1021/bm800512e
Publication Date (Web): July 29, 2008
Copyright © 2008 American Chemical Society
* To whom correspondence should be addressed. Phone: 850-283-6023. Fax: 850-283-6090. E-mail: matt.eby.ctr@tyndall.af.mil (D.M.E.); glenn.johnson@tyndall.af.mil (G.R.J.).
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†

Universal Technology Corporation.

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‡

Applied Research Associates, Inc.

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§

Air Force Research Laboratory.

Abstract

Abstract Image

Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of self-synthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.

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History

  • Published In Issue September 08, 2008
  • Article ASAPJuly 29, 2008
  • Received: May 8, 2008
    Revised: June 17, 2008

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