Thiol/Acrylate-Modified PEO-PPO-PEO Triblocks Used as Reactive and Thermosensitive Copolymers

Guoguang Niu, Hongbin Zhang, Li Song, Xiaopeng Cui, Hui Cao, Yudong Zheng, Siquan Zhu*†, Zhou Yang and Huai Yang*
School of Materials Science and Engineering, University of Science and Technology Beijing, China
Biomacromolecules, 2008, 9 (10), pp 2621–2628
DOI: 10.1021/bm800573e
Publication Date (Web): August 19, 2008
Copyright © 2008 American Chemical Society
* To whom correspondence should be addressed. Tel.: +86-10-62333974 (H.Y.). Fax: +86-10-623333974 (H.Y.). E-mail: yanghuai@mater.ustb.edu.cn (H.Y.); siquanzhu@sina.com (S.Z.).
,
†

Beijing Tongren Hospital Eye Center, China.

This article is part of the Chinese Section special issue.

Abstract

Abstract Image

The reactive thermal-sensitive hydrogels, which combined the reversible thermosensitive and mild reactive property, were designed based on thiol-ene reaction in physiological conditions between thiol and acrylate capped thermosensitive Poloxamer 188. The modified P188A, P188SH, and their reactivity were characterized by 1H NMR, FT-IR, GPC, DSC, Ellman method, and Rheometer. It was found that the thiol-ene reaction was pH and thermal-sensitive. There was 77.7% SH involved into the reaction at 37.0 °C and pH 7.4 within the first 30 min. The most of molecules reacted as CC/SH mol ratio was 1.5. The exothermic thiol-ene reaction was mild, with about ΔH = −91.18 J/g changes. The multiblocks or network structure limited the dissolution of hydrogel, correspondingly the gel’s duration and the release time of methylene blue were prolonged to 124 h. The experimental results indicated the reactive thermal-sensitive hydrogel’s potential applications in drug delivery, tissue engineering, and cell encapsulation.

View: Full Text HTML | Hi-Res PDF | PDF w/ Links

Tools

History

  • Published In Issue October 13, 2008
  • Article ASAPAugust 19, 2008
  • Received: May 22, 2008
    Revised: July 4, 2008

Recommend & Share

Related Content

Other ACS content by these authors: