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Swimming into the Future of Drug Discovery: In Vivo Chemical Screens in Zebrafish

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Teresa V. Bowman and Leonard I. Zon*

Stem Cell Program and Division of Hematology and Oncology, Children’s Hospital Boston and Howard Hughes Medical Institute, 300 Longwood Avenue, Boston, Massachusetts 02115

ACS Chem. Biol., 2010, 5 (2), pp 159–161

DOI: 10.1021/cb100029t

Publication Date (Web): February 19, 2010

* Corresponding author, zon@enders.tch.harvard.edu.

Section:

Pharmacology

Abstract

In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure−activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials
Saji George, Tian Xia, Robert Rallo, Yan Zhao, Zhaoxia Ji, Sijie Lin, Xiang Wang, Haiyuan Zhang, Bryan France, David Schoenfeld, Robert Damoiseaux, Rong Liu, Shuo Lin, Kenneth A. Bradley, Yoram Cohen, and André E Nel
ACS Nano2011 5 (3), 1805-1817
- Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials
  Saji George, Tian Xia, Robert Rallo, Yan Zhao, Zhaoxia Ji, Sijie Lin, Xiang Wang, Haiyuan Zhang, Bryan France, David Schoenfeld, Robert Damoiseaux, Rong Liu, Shuo Lin, Kenneth A. Bradley, Yoram Cohen, and André E Nel
  ACS Nano2011 5 (3), 1805-1817
  Because of concerns about the safety of a growing number of engineered nanomaterials (ENM), it is necessary to develop high-throughput screening and in silico data transformation tools that can speed up in vitro hazard ranking. Here, we report the use of ...
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