When Conjugated Polymers Meet Amyloid Fibrils

Cliff I. Stains, and Indraneel Ghosh, *
Department of Chemistry, University of Arizona, 1306 E. University Boulevard, Tucson, Arizona 85721
ACS Chem. Biol., 2007, 2 (8), pp 525–528
DOI: 10.1021/cb700165v
Publication Date (Web): August 17, 2007
Copyright © 2007 American Chemical Society
* Corresponding author, ghosh@email.arizona.edu.

Abstract

Abstract Image

In the early 1900s, Alois Alzheimer diagnosed one of his patients with a devastating neurological impairment, and this form of dementia became known as Alzheimer’s disease (AD). Much research over the past century has clearly established that numerous human diseases, ranging from AD and Parkinson’s disease to dialysis-related amyloidosis, are best characterized by the abnormal aggregation of specific proteins. However, in the case of AD, the true toxic molecular species is still debated. Thus, the recent development of new diagnostic agents capable of distinguishing between different morphologies of aggregated proteins is of much interest.

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History

  • Received: August 06, 2007
    Accepted: August 06, 2007

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