Bright Ideas for Chemical Biology

Luke D. Lavis†§ and Ronald T. Raines†‡*
† Department of Chemistry
‡ Department of Biochemistry, University of WisconsinMadison, Madison, Wisconsin 53706
ACS Chem. Biol., 2008, 3 (3), pp 142–155
DOI: 10.1021/cb700248m
Publication Date (Web): March 20, 2008
Copyright © 2008 American Chemical Society
§

Current address: Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147

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* Corresponding author, rtraines@wisc.edu.

Abstract

Abstract Image

Small-molecule fluorescent probes embody an essential facet of chemical biology. Although numerous compounds are known, the ensemble of fluorescent probes is based on a modest collection of modular “core” dyes. The elaboration of these dyes with diverse chemical moieties is enabling the precise interrogation of biochemical and biological systems. The importance of fluorescence-based technologies in chemical biology elicits a necessity to understand the major classes of small-molecule fluorophores. Here, we examine the chemical and photophysical properties of oft-used fluorophores and highlight classic and contemporary examples in which utility has been built upon these scaffolds.

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History

  • Published In Issue March 20, 2008
  • Article ASAPMarchMarch 2020, 20082008
  • Received: December 1, 2007
    Accepted: February 26, 2008
    Revised: January 18, 2008

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