Ester Bonds in Prodrugs

Related Content

• Regioisomeric SCFA Attachment to Hexosamines Separates Metabolic Flux from Cytotoxicity and MUC1 SuppressionACS Chemical Biology

  • Regioisomeric SCFA Attachment to Hexosamines Separates Metabolic Flux from Cytotoxicity and MUC1 Suppression

    Udayanath Aich, Christopher T. Campbell, Noha Elmouelhi, Christopher A. Weier, S.-Gopalan Sampathkumar, Sean S. Choi and Kevin J. Yarema
    ACS Chemical Biology 2008 3 (4), pp 230–240

    Abstract: Chemical biology studies, exemplified by metabolic glycoengineering experiments that employ short chain fatty acid (SCFA)-hexosamine monosaccharide hybrid molecules, often suffer from off-target effects. Here we demonstrate that systematic structure–...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF
• Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating MachineryACS Chemical Biology

  • Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery

    Kerry Routenberg Love, Renuka K. Pandya, Eric Spooner and Hidde L. Ploegh
    ACS Chemical Biology 2009 4 (4), pp 275–287

    Abstract: Protein modification by ubiquitin (Ub) and ubiquitin-like modifiers (Ubl) requires the action of activating (E1), conjugating (E2), and ligating (E3) enzymes and is a key step in the specific destruction of proteins. Deubiquitinating enzymes (DUBs) ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

Other ACS content by these authors:

• Luke D. Lavis

See also: