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Article

Multistep Synthesis on SU-8: Combining Microfabrication and Solid-Phase Chemistry on a Single Material

Supporting Info

Gabriel Cavalli,^†^# Shahanara Banu,^† Rohan T. Ranasinghe,^† Graham R. Broder,^† Hugo F. P. Martins,^† Cameron Neylon,^†^‡ Hywel Morgan,^§ Mark Bradley, and Peter L. Roach*^†

School of Chemistry, Highfield Campus, University of Southampton, Southampton SO17 1BJ, U.K., Isis Pulsed Neutron and Muon Facility, Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, U.K., School of Electronic and Computing Sciences, Highfield Campus, University of Southampton, Southampton SO17 1BJ, U.K., and School of Chemistry, The University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, U.K.

J. Comb. Chem., 2007, 9 (3), pp 462–472

DOI: 10.1021/cc060079p

Publication Date (Web): April 7, 2007

†

School of Chemistry, University of Southampton.

Current address: School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, GU2 7XH, U.K.

‡

Isis Pulsed Neutron and Muon Facility, Rutherford Appleton Laboratory.

School of Electronic and Computing Sciences, University of Southampton.

School of Chemistry, The University of Edinburgh.

To whom correspondence should be addressed. E-mail: P.L.Roach@ soton.ac.uk.

Abstract

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

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