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Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).
Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009
Roland E. Dolle, Bertrand Le Bourdonnec, Karin Worm, Guillermo A. Morales, Craig J. Thomas, and Wei ZhangJournal of Combinatorial Chemistry2010 12 (6), 765-806Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009
Roland E. Dolle, Bertrand Le Bourdonnec, Karin Worm, Guillermo A. Morales, Craig J. Thomas, and Wei ZhangJournal of Combinatorial Chemistry2010 12 (6), 765-806
Solid-Phase Synthesis of Amino- and Carboxyl-Functionalized Unnatural α-Amino Acid Amides
William L. Scott, Ziniu Zhou, Jacek G. Martynow and Martin J. O’DonnellOrganic Letters2009 11 (16), 3558-3561Solid-Phase Synthesis of Amino- and Carboxyl-Functionalized Unnatural α-Amino Acid Amides
William L. Scott, Ziniu Zhou, Jacek G. Martynow and Martin J. O’DonnellOrganic Letters2009 11 (16), 3558-3561A new solid-phase synthesis efficiently incorporates three different substituents (from R1-X, R2-CO2H, and R3-NH2) into a glycine-based peptidomimetic scaffold. The synthetic sequence is general and is typically accomplished in >50% overall isolated ...
Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction
William L. Scott, Jordi Alsina, Christopher O. Audu, Evgenii Babaev, Linda Cook, Jeffery L. Dage, Lawrence A. Goodwin, Jacek G. Martynow, Dariusz Matosiuk, Miriam Royo, Judith G. Smith, Andrew T. Strong, Kirk Wickizer, Eric M. Woerly, Ziniu Zhou and Martin J. O’DonnellJournal of Combinatorial Chemistry2009 11 (1), 14-33Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction
William L. Scott, Jordi Alsina, Christopher O. Audu, Evgenii Babaev, Linda Cook, Jeffery L. Dage, Lawrence A. Goodwin, Jacek G. Martynow, Dariusz Matosiuk, Miriam Royo, Judith G. Smith, Andrew T. Strong, Kirk Wickizer, Eric M. Woerly, Ziniu Zhou and Martin J. O’DonnellJournal of Combinatorial Chemistry2009 11 (1), 14-33Distributed Drug Discovery (D3) proposes solving large drug discovery problems by breaking them into smaller units for processing at multiple sites. A key component of the synthetic and computational stages of D3 is the global rehearsal of prospective ...
Distributed Drug Discovery, Part 3: Using D3 Methodology to Synthesize Analogs of an Anti-Melanoma Compound
William L. Scott, Christopher O. Audu, Jeffery L. Dage, Lawrence A. Goodwin, Jacek G. Martynow, Laura K. Platt, Judith G. Smith, Andrew T. Strong, Kirk Wickizer, Eric M. Woerly and Martin J. O’DonnellJournal of Combinatorial Chemistry2009 11 (1), 34-43Distributed Drug Discovery, Part 3: Using D3 Methodology to Synthesize Analogs of an Anti-Melanoma Compound
William L. Scott, Christopher O. Audu, Jeffery L. Dage, Lawrence A. Goodwin, Jacek G. Martynow, Laura K. Platt, Judith G. Smith, Andrew T. Strong, Kirk Wickizer, Eric M. Woerly and Martin J. O’DonnellJournal of Combinatorial Chemistry2009 11 (1), 34-43For the successful implementation of Distributed Drug Discovery (D3) (outlined in the accompanying Perspective), students, in the course of their educational laboratories, must be able to reproducibly make new, high quality, molecules with potential for ...
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- Published In Issue January 12, 2009
- Article ASAPDecember 23, 2008
- Received: November 14, 2008
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