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Facial Rejuvenation in the Triangle of ROS

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Andrei P. Sommer* and Dan Zhu

Institute of Micro and Nanomaterials, University of Ulm, 89081 Ulm, Germany

Cryst. Growth Des., 2009, 9 (10), pp 4250–4254

DOI: 10.1021/cg900688g

Publication Date (Web): August 12, 2009

*To whom correspondence should be addressed. E-mail: andrei.sommer@uni-ulm.de.

Section:

Toxicology

Abstract

Recently, we introduced into the conventional catalogue of biological aging a new determinant: ordered interfacial water layers. The discovery of their tunability with skin-tolerated levels of 670 nm light inspired a model, which suggested that the light, by interaction with ordered interfacial water layers in the extracellular matrix, would reverse elastin degeneration. We validated the model in a 10 month self-experiment and arrived at an effective facial rejuvenation program. Importantly, during the experimental phase we avoided extreme oxidative stressors, in particular exposure to extensive ultraviolet and infrared radiation as well as air pollution. Here we report on the adaptation of our model to the extreme oxidative stress levels prevalent in numerous polluted megacities. The results of the extension comprise a new understanding of the protective function of the skin acid mantle, new predictive insight into effects of reactive oxygen species (ROS) on interfacial water layers, and their implication in processes of biological aging, including depletion of follicular stem cell reservoirs and telomere shortening, and led to the design of an accelerated skin rejuvenation method.

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Breathing Volume into Interfacial Water with Laser Light
Andrei P. Sommer, Kai F. Hodeck, Dan Zhu, Alexander Kothe, Kathrin M. Lange, Hans-Jörg Fecht, and Emad F. Aziz
The Journal of Physical Chemistry Letters2011 2 (6), 562-565
- Breathing Volume into Interfacial Water with Laser Light
  Andrei P. Sommer, Kai F. Hodeck, Dan Zhu, Alexander Kothe, Kathrin M. Lange, Hans-Jörg Fecht, and Emad F. Aziz
  The Journal of Physical Chemistry Letters2011 2 (6), 562-565
  The molecular structure of nanoscopic interfacial water layers is changed by irradiation with 670 nm laser light, a wavelength to which bulk water is practically transparent. Whereas the phenomenon was confirmed in several experimental studies, its ...
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