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Research Article

A Simple Method for Aligning Many Protein Sequences

Peter Bladon^†

Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL Scotland, United Kingdom

J. Chem. Inf. Comput. Sci., 2001, 41 (2), pp 278–280

DOI: 10.1021/ci9904362

Publication Date (Web): February 6, 2001

†

Present address: Interprobe Chemical Services, Gallowhill House, Larch Ave., Lenzie, Kirkintilloch, Glasgow, Scotland G66 4HX. Telephone/Facsimile: +44-(0)141-578-1109. E-mail: cbas25@strath.ac.uk. URL: http://www.interprobe.co.uk.

Abstract

A simple extension of the Needleman and Wunsch algorithm for aligning pairs of protein sequences allows it to be used for the efficient generation of very large multiple-sequence alignments whose members are similar. This technique could have applications in a broad range of high-volume genomics projects.

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