Oxidative Nucleobase Modifications Leading to Strand Scission

Cynthia Burrows was trained in organic photochemistry with Stanley Cristol (B.A., University of Colorado, 1975), organic reaction mechanisms with Barry Carpenter (Ph.D., Cornell University, 1982), and supramolecular chemistry with Jean-Marie Lehn (NSF-CNRS postdoctoral fellow, Université Louis Pasteur, 1981−1983). Her independent academic career was launched at the State University of New York at Stony Brook; in 1995 she moved to the University of Utah as Professor of Chemistry. Research in the Burrows group currently includes transition metal-mediated oxidation of nucleic acids and the design of DNA-targeted reagents.

James Muller was born in Mineola, NY, in 1964. He received a B.A. degree in chemistry in 1986 from the University of New York at Buffalo and a Ph.D. in 1992 with Kenneth Takeuchi at the University of New York at Buffalo. He worked as a postdoctoral fellow at the University of New York at Stony Brook from 1991 to 1995 with Cynthia Burrows. He received an American Cancer Society postdoctoral fellowship in 1992 and an American Institute of Chemists Foundation postdoctoral student award in 1995. He is currently a Research Assistant Professor at the University of Utah. His research interests include the design and study of nucleic acid structural probes.