Carbohydrate Structural Determination by NMR Spectroscopy:  Modern Methods and Limitations^†

Jens Ø. Duus received his M.Sc. degree in Chemical Engineering from the Technical University of Denmark in 1989. Following this, he continued his graduate study with Professor Klaus Bock at the Carlsberg Laboratory and was granted his Ph.D. degree from the Technical University of Denmark in 1993. During his graduate study he was twice a Visiting Scientist at Dupont Experimental Station in Wilmington, DE working with Dr. S. Sabesan. From 1993 to 1994 he was a Research Fellow in Chemistry at the Beckman Institute at the California Institute of Technology working with Professor Harry B. Gray. After returning to the Carlsberg Laboratory, he was appointed Senior Scientist. His main fields of research are structure and dynamics of biomolecules with emphasis on carbohydrates using NMR and fluroescence.

Charlotte Held Gotfredsen received her M.Sc. degree in 1995 from Odense University, Denmark. She continued her graduate studies at Odense University with Dr. Jens Peter Jacobsen and Professor Jesper Wengel working on the synthesis and NMR structural studies of modified oligonucleotides and received her Ph.D. degree in Chemistry in 1998. During her Ph.D. study Charlotte spent a year with Professor Juli Feigon at the University of California, Los Angeles, CA. Since May 1998 she has been working as a Postdoctoral Fellow in the Department of Chemistry at the Carlsberg Laboratory in Copenhagen, Denmark. In 1999, Charlotte received a two-year personal grant (talent project) from the Danish Technical Research Council. Her current field of research is centered around the structural analysis of minute sample amounts and solid-phase bound compounds with emphasis on using the newly developed high-resolution MAS NMR probes and other microcoil NMR probes.

Klaus Bock is Professor at Carlsberg Laboratory, Department of Chemistry and Research Director at Carlsberg Research Center. After receiving his M.Sc. degree in Civil Engineering (Chemistry), 1968, he obtained his Ph.D. degree in Organic Chemistry, 1970, both at The Technical University of Denmark. He has been employed as Assistant Professor in the Department of Organic Chemistry, Technical University of Denmark in Lyngby (1970−1972), Associate Professor (Lecturer) in the Department of Organic Chemistry, Technical University of Denmark (1972−1988), Visiting Associate Professor, Department of Chemistry, Univeristy of British Columbia, Vancouver, B.C., Canada (1974−1975), Professor, Head of Chemistry Department, Carlsberg Laboratory, Copenhagen, Denmark (1988−present), Research Director, Carlsberg Research Center (1993−present), and Group Vice President for Research (1999−present). He has received several international awards and he has considerable representation on international committees, scientific advisory boards and journals, and boards. He has published over 256 refereed papers in international journals within the area of analytical and synthetic carbohydrate chemistry.