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Bromination of Acetanilide

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Paul F. Schatz

University of Wisconsin-Madison, Madison, WI 53706

J. Chem. Educ., 1996, 73 (3), p 267

DOI: 10.1021/ed073p267

Publication Date (Web): March 1, 1996

Section:

History, Education, and Documentation

Abstract

A general procedure for bromination of aromatic compounds activated with electron donating substituents such as acetamido, hydroxyl, or ether groups is described. Bromine is generated in situ from potassium bromate and hydrobromic acid. This procedure avoids the hazards associated with direct handling of bromine or bromine solutions. The results from seven aromatic ethers and anilides are reported.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Laboratory Instruction

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Bromine

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Received: August 03, 2009

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Bromination of Acetanilide

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Directive effects in electrophilic aromatic substitution. An organic chemistry experiment

The Ethylene Ketal Protecting Group Revisited: The Synthesis of 4-Hydroxy-4,4-diphenyl-2-butanone

A New Recyclable Ditribromide Reagent for Efficient Bromination under Solvent Free Condition

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