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Carbon Monoxide Poisoning: Some Surprising Aspects of the Equilibrium between Hemoglobin, Carbon Monoxide, and Oxygen

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N. M. Senozan and J. A. Devore

Department of Chemistry and Biochemistry, California State University, Long Beach, CA 90840

J. Chem. Educ., 1996, 73 (8), p 767

DOI: 10.1021/ed073p767

Publication Date (Web): August 1, 1996

Section:

History, Education, and Documentation

Abstract

Carbon monoxide poisoning and some aspects of the equilibrium between carbon monoxide, oxygen, and hemoglobin are discussed within the framework of Haldane's laws. The effect of CO on respiration is analyzed quantitatively using oxygen dissociation curves of hemoglobin in presence of carboxyhemoglobin. The analysis shows that the adverse cardiovascular consequences of chronic CO exposure are unlikely to be due to reduced O2 transport capability of hemoglobin.