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Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Instrumentation and Applications
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Abstract
This article introduces educators and researchers to the theory, principles, instrumentation, and some applications of MALDI-MS. Reflectron time-of-flight (TOF) mass analyzers are described in detail, since TOF is the most common mass analyzer for ions produced by MALDI. Several excellent reviews give a more detailed account of MALDI-MS.
Keywords (Audience):
Second-Year UndergraduateKeywords (Domain):
Analytical ChemistryKeywords (Subject):
Mass SpectrometryCiting Articles
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This article has been cited by 11 ACS Journal articles (5 most recent appear below).
Using the Mini-Session Course Format To Train Students in the Practical Aspects of Modern Mass Spectrometry
Dale A. Rosado, Jr., Tina S. Masterson, and Douglas S. MastersonJournal of Chemical Education2011 88 (2), 178-183Using the Mini-Session Course Format To Train Students in the Practical Aspects of Modern Mass Spectrometry
Dale A. Rosado, Jr., Tina S. Masterson, and Douglas S. MastersonJournal of Chemical Education2011 88 (2), 178-183Mass spectrometry (MS) has been gaining in popularity in recent years owing in large part to the development of soft-ionization techniques such as matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI). These soft-ionization ...
Identification of Fatty Acids, Phospholipids, and Their Oxidation Products Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Electrospray Ionization Mass Spectrometry
Christopher W. Harmon, Stephen A. Mang, John Greaves and Barbara J. Finlayson-PittsJournal of Chemical Education2010 87 (2), 186-189Identification of Fatty Acids, Phospholipids, and Their Oxidation Products Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Electrospray Ionization Mass Spectrometry
Christopher W. Harmon, Stephen A. Mang, John Greaves and Barbara J. Finlayson-PittsJournal of Chemical Education2010 87 (2), 186-189Electrospray ionization mass spectrometry (ESI-MS) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) have found increasing application in the analysis of biological samples. Using these techniques to solve problems in analytical ...
Illustrating the Concepts of Isotopes and Mass Spectrometry in Introductory Courses: A MALDI-TOF Mass Spectrometry Laboratory Experiment
Nancy Carter Dopke and Timothy Neal LovettJournal of Chemical Education2007 84 (12), 1968Illustrating the Concepts of Isotopes and Mass Spectrometry in Introductory Courses: A MALDI-TOF Mass Spectrometry Laboratory Experiment
Nancy Carter Dopke and Timothy Neal LovettJournal of Chemical Education2007 84 (12), 1968Mass spectrometry is a widely used and versatile tool for scientists in many different fields. Soft ionization techniques such as matrix-assisted laser desorption/ionization (MALDI) allow for the analysis of biomolecules, polymers, and clusters. This ...
Submicrosecond Surface-Induced Dissociation of Peptide Ions in a MALDI TOF MS
Chaminda M. Gamage, Facundo M. Fernández, Krishnamoorthy Kuppannan, and Vicki H. WysockiAnalytical Chemistry2004 76 (17), 5080-5091Submicrosecond Surface-Induced Dissociation of Peptide Ions in a MALDI TOF MS
Chaminda M. Gamage, Facundo M. Fernández, Krishnamoorthy Kuppannan, and Vicki H. WysockiAnalytical Chemistry2004 76 (17), 5080-5091Surface-induced dissociation (SID) has been implemented in a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer (MALDI TOF MS), allowing production of tandem mass spectrometric information for peptide ions (MALDI TOF SID TOF). ...
Identifying a Protein by MALDI-TOF Mass Spectrometry: An Experiment for the Undergraduate Laboratory
Anne E. Counterman , Matthew S. Thompson and David E. ClemmerJournal of Chemical Education2003 80 (2), 177Identifying a Protein by MALDI-TOF Mass Spectrometry: An Experiment for the Undergraduate Laboratory
Anne E. Counterman , Matthew S. Thompson and David E. ClemmerJournal of Chemical Education2003 80 (2), 177Matrix-assisted laser desorption ionization time-of-flight (MALDI–TOF) mass spectrometry has become a valuable tool for performing routine biochemical analyses. A common procedure for protein identification involves using tryptic digestion to obtain ...
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- Received: August 03, 2009
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