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Perfect Strangers: Inorganic Photochemistry and Nucleic Acids
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Abstract
The applications of inorganic photochemistry to nucleic acid chemistry are discussed. A brief review of nucleic acid structure is given. Methods for probing DNA using emissive inorganic complexes are discussed. Photoreactions that damage DNA by hydrogen atom transfer from sugar or electron abstraction from guanine are presented. The method of photochemical footprinting using a diplatinum photocatalyst is described. The final section discusses advances in combinatorial selection experiments that increase the urgency for rapid screening methods such as those derived from inorganic photochemistry.
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).

Theoretical Analysis of the Triplet Excited State of the [Pt2(H2P2O5)4]4- Ion and Comparison with Time-Resolved X-ray and Spectroscopic Results
Irina V. Novozhilova, Anatoliy V. Volkov, and Philip CoppensJournal of the American Chemical Society2003 125 (4), 1079-1087Theoretical Analysis of the Triplet Excited State of the [Pt2(H2P2O5)4]4- Ion and Comparison with Time-Resolved X-ray and Spectroscopic Results
Irina V. Novozhilova, Anatoliy V. Volkov, and Philip CoppensJournal of the American Chemical Society2003 125 (4), 1079-1087A full understanding of the nature of excited states of transition metal complexes is important for understanding their chemical reactivity and role as intermediates in photochemically induced reactions. The ground and excited states of the [Pt2(pop)4]4- ...

Effect of DNA Scaffolding on Intramolecular Electron Transfer Quenching of a Photoexcited Ruthenium(II) Polypyridine Naphthalene Diimide
Dabney W. Dixon, Nancy B. Thornton, Vera Steullet, and Thomas NetzelInorganic Chemistry1999 38 (24), 5526-5534Effect of DNA Scaffolding on Intramolecular Electron Transfer Quenching of a Photoexcited Ruthenium(II) Polypyridine Naphthalene Diimide
Dabney W. Dixon, Nancy B. Thornton, Vera Steullet, and Thomas NetzelInorganic Chemistry1999 38 (24), 5526-5534A RuII(bpy)2(bpy-CONH)2+ donor covalently attached by way of a CH2CH2CH2 linker to a naphthalene diimide (NDI) acceptor has been synthesized. The complex intercalates in calf thymus DNA, as indicated by the hypochromism of the naphthalene diimide moiety ...

Conformation-Dependent Cleavage of Hairpin and Triplex Nucleic Acids by a Temperature-Insensitive Photonuclease
Suzanne A. Ciftan and H. Holden ThorpJournal of the American Chemical Society1998 120 (39), 9995-10000Conformation-Dependent Cleavage of Hairpin and Triplex Nucleic Acids by a Temperature-Insensitive Photonuclease
Suzanne A. Ciftan and H. Holden ThorpJournal of the American Chemical Society1998 120 (39), 9995-10000Photolysis of Pt2(pop)44- in the presence of duplex DNA produces strand scission via abstraction of the 4- and 5-hydrogen atoms (pop = P2O5H22-). The cleavage intensities are higher for single-stranded DNA compared to those for duplex DNA because of ...

Intramolecular Quenching of Porphyrin Fluorescence by a Covalently Linked Ferrocene in DNA Scaffolding
Nancy B. Thornton, Hania Wojtowicz, Thomas Netzel, and Dabney W. DixonThe Journal of Physical Chemistry B1998 102 (11), 2101-2110Intramolecular Quenching of Porphyrin Fluorescence by a Covalently Linked Ferrocene in DNA Scaffolding
Nancy B. Thornton, Hania Wojtowicz, Thomas Netzel, and Dabney W. DixonThe Journal of Physical Chemistry B1998 102 (11), 2101-2110Intramolecular quenching of fluorescence from a cationic porphyrin by a covalently attached ferrocene in both solution and DNA is reported. Two ferrocenyl porphyrins have been prepared, tris(4-N-methylpyridiniumyl), mono(phenyl-OCH2CH2ferrocene)porphyrin, ...
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- Received: August 03, 2009
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