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Electron Transfer Reactions in DNA
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Abstract
This paper introduces to an active and provocative area of current research. It describes motivations for studying electron transfer (ET) chemistry in general and ET reactions in DNA in particular. A rate expression for a semiclassical electron transfer model is given along with a description of appropriate conditions for its use. Formulas describing the distance dependence of electronic coupling (HAB) and solvent reorganization energy are also provided as a basis for understanding and interpreting recent experiments. Three different long-range ET experiments are presented, and their results are compared with one another and with the results of similar experiments in proteins. Discrepancies and difficulties are noted, and suggestions for new experiments are made.
Keywords (Audience):
Upper-Division UndergraduateKeywords (Domain):
BiochemistryKeywords (Feature):
Symposium ReportKeywords (Subject):
Biophysical ChemistryCiting Articles
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This article has been cited by 7 ACS Journal articles (5 most recent appear below).
Photoinduced Oxidative DNA Damage Revealed by an Agarose Gel Nicking Assay: A Biophysical Chemistry Laboratory Experiment
Vladimir Shafirovich , Carolyn Singh and Nicholas E. GeacintovJournal of Chemical Education2003 80 (11), 1297Photoinduced Oxidative DNA Damage Revealed by an Agarose Gel Nicking Assay: A Biophysical Chemistry Laboratory Experiment
Vladimir Shafirovich , Carolyn Singh and Nicholas E. GeacintovJournal of Chemical Education2003 80 (11), 1297Oxidative damage of DNA molecules associated with electron-transfer reactions is an important phenomenon in living cells, which can lead to mutations and contribute to carcinogenesis and the aging processes. This article describes the design of several ...
Synthesis and Stability of Oligodeoxynucleotides Containing C8-Labeled 2‘-Deoxyadenosine: Novel Redox Nucleobase Probes for DNA-Mediated Charge-Transfer Studies
Mark T. Tierney and Mark W. GrinstaffOrganic Letters2000 2 (22), 3413-3416Synthesis and Stability of Oligodeoxynucleotides Containing C8-Labeled 2‘-Deoxyadenosine: Novel Redox Nucleobase Probes for DNA-Mediated Charge-Transfer Studies
Mark T. Tierney and Mark W. GrinstaffOrganic Letters2000 2 (22), 3413-3416An efficient and convenient synthetic strategy to redox-labeled C8-derivatives of 2-deoxyadenosine is described. The Pd(0) cross-coupling chemistry is amenable to both oxidative and reductive redox probes. The corresponding phosphoramidites of ...
Electron Spin Resonance Study of Electron Transfer in DNA: Inter-Double-Strand Tunneling Processes
Zhongli Cai and Michael D. SevillaThe Journal of Physical Chemistry B2000 104 (29), 6942-6949Electron Spin Resonance Study of Electron Transfer in DNA: Inter-Double-Strand Tunneling Processes
Zhongli Cai and Michael D. SevillaThe Journal of Physical Chemistry B2000 104 (29), 6942-6949In this work, we employ frozen glassy aqueous (D2O) solutions of DNA at various concentrations in order to test for inter-DNA-double-strand electron transfer, i.e., transfer from one DNA double strand to another. Electrons generated by radiation are ...
Effect of DNA Scaffolding on Intramolecular Electron Transfer Quenching of a Photoexcited Ruthenium(II) Polypyridine Naphthalene Diimide
Dabney W. Dixon, Nancy B. Thornton, Vera Steullet, and Thomas NetzelInorganic Chemistry1999 38 (24), 5526-5534Effect of DNA Scaffolding on Intramolecular Electron Transfer Quenching of a Photoexcited Ruthenium(II) Polypyridine Naphthalene Diimide
Dabney W. Dixon, Nancy B. Thornton, Vera Steullet, and Thomas NetzelInorganic Chemistry1999 38 (24), 5526-5534A RuII(bpy)2(bpy-CONH)2+ donor covalently attached by way of a CH2CH2CH2 linker to a naphthalene diimide (NDI) acceptor has been synthesized. The complex intercalates in calf thymus DNA, as indicated by the hypochromism of the naphthalene diimide moiety ...
Photophysical Quenching Mediated by Guanine Groups in Pyrenyl-N-alkylbutanoamide End-Labeled Oligonucleotides
Eran Zahavy and Marye Anne FoxThe Journal of Physical Chemistry B1999 103 (43), 9321-9327Photophysical Quenching Mediated by Guanine Groups in Pyrenyl-N-alkylbutanoamide End-Labeled Oligonucleotides
Eran Zahavy and Marye Anne FoxThe Journal of Physical Chemistry B1999 103 (43), 9321-9327Two series of pyrenyl-N-alkylbutanoamide end-labeled oligonucleotides have been prepared as models for photophysical quenching along DNA segments. Pyrenebutanoic acid (P) has been attached through 6-aminohexyl or 3-aminopropyl linkers to the 5 edge of an ...
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- Received: August 03, 2009
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