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Commentary
The Art and Science of Organic and Natural Products Synthesis
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Abstract
In this article, the history of the art and science of organic and natural products synthesis is briefly reviewed and the state of the art is discussed. The impact of this discipline on biology and medicine is amply demonstrated with examples, and projections for future developments in the field are made.
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Natural ProductsCiting Articles
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This article has been cited by 5 ACS Journal articles (5 most recent appear below).
Acylation, Diastereoselective Alkylation, and Cleavage of an Oxazolidinone Chiral Auxiliary
Thomas E. Smith , David P. Richardson , George A. Truran , Katherine Belecki and Megumi OnishiJournal of Chemical Education2008 85 (5), 695Acylation, Diastereoselective Alkylation, and Cleavage of an Oxazolidinone Chiral Auxiliary
Thomas E. Smith , David P. Richardson , George A. Truran , Katherine Belecki and Megumi OnishiJournal of Chemical Education2008 85 (5), 695An introduction to the concepts and experimental techniques of diastereoselective synthesis using a chiral auxiliary is described. The 4-benzyl-2-oxazolidinone chiral auxiliary developed by Evans is acylated with propionic anhydride under mild conditions ...
Synthesis of Methyl Diantilis, a Commercially Important Fragrance
William H. Miles and Katelyn B. ConnellJournal of Chemical Education2006 83 (2), 285Synthesis of Methyl Diantilis, a Commercially Important Fragrance
William H. Miles and Katelyn B. ConnellJournal of Chemical Education2006 83 (2), 285This experiment describes the synthesis of a family of fragrances, including the commercially important Methyl Diantilis, that were covered by a U.S. patent in 1987. The first step in the synthesis is the reduction of 3-ethoxy-4-hydroxybenzaldehyde (ethyl ...
Incorporation of Medicinal Chemistry into the Organic Chemistry Curriculum
David C. ForbesJournal of Chemical Education2004 81 (7), 975Incorporation of Medicinal Chemistry into the Organic Chemistry Curriculum
David C. ForbesJournal of Chemical Education2004 81 (7), 975An optional exercise designed for students enrolled in the lecture component of organic chemistry is described. This exercise, designed for students at the sophomore level, focuses on a drug of medicinal relevance. After having the instructor approve a ...
Chelation-Controlled Bergman Cyclization: Synthesis and Reactivity of Enediynyl Ligands
Amit Basak, Subrata Mandal, and Subhendu Sekhar BagChemical Reviews2003 103 (10), 4077-4094Chelation-Controlled Bergman Cyclization: Synthesis and Reactivity of Enediynyl Ligands
Amit Basak, Subrata Mandal, and Subhendu Sekhar BagChemical Reviews2003 103 (10), 4077-4094
Cyclization of the Monoterpene Citronellal to Isopulegol: A Biomimetic Natural Product Synthesis
Bruce L. Jensen , Ahmed Malkawi and Vanessa McGowanJournal of Chemical Education2000 77 (11), 1474Cyclization of the Monoterpene Citronellal to Isopulegol: A Biomimetic Natural Product Synthesis
Bruce L. Jensen , Ahmed Malkawi and Vanessa McGowanJournal of Chemical Education2000 77 (11), 1474Cyclization of the monoterpene (S)-(--)-citronellal takes place rapidly in the presence of tin(IV) chloride in methylene chloride at 0 °C, affording the cyclic monoterpene isopulegol in a yield of 85%. The experiment reported here mimics the reaction ...
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- Received: August 03, 2009
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