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Synthesis of Complex Natural Products as a Vehicle for Student-Centered, Problem-Based Learning

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Kevin C. Cannon and Grant R. Krow

Department of Chemistry, Temple University, Philadelphia, PA 19122

J. Chem. Educ., 1998, 75 (10), p 1259

DOI: 10.1021/ed075p1259

Publication Date (Web): October 1, 1998

Section:

History, Education, and Documentation

Abstract

Management strategies for upper-level undergraduate and graduate courses in organic synthesis at Temple University are described, and both student and faculty responsibilities are discussed. Using natural product synthesis as a vehicle, students choose a synthetic problem from the literature, identify the knowledge needed to solve the problem, explore resources for attaining that knowledge, identify the goals and criteria for a successful synthetic plan, and create and do assessments of their work. The method is an example of teacher-guided, student-directed, interdependent, small-group, problem-based learning.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Laboratory Instruction

Keywords (Pedagogy):

Problem Solving / Decision Making

Keywords (Subject):

Synthesis

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This article has been cited by 6 ACS Journal articles (5 most recent appear below).

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Journal of Chemical Education2012 89 (1), 52-57
- The Development and Implementation of a Problem-Based Learning Format in a Fourth-Year Undergraduate Synthetic Organic and Medicinal Chemistry Laboratory Course
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  Journal of Chemical Education2012 89 (1), 52-57
  The fourth-year undergraduate synthetic organic and medicinal chemistry laboratory course at the University of Ottawa was transformed from a traditional laboratory format to a problem-based learning (PBL) format. Authentic problems were developed that ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Developing Problem-Solving Skills through Retrosynthetic Analysis and Clickers in Organic Chemistry
Alison B. Flynn
Journal of Chemical Education2011 88 (11), 1496-1500
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  Journal of Chemical Education2011 88 (11), 1496-1500
  A unique approach to teaching and learning problem-solving and critical-thinking skills in the context of retrosynthetic analysis is described. In this approach, introductory organic chemistry students, who typically see only simple organic structures, ...
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Making a Chemical Rainbow
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Journal of Chemical Education2010 87 (5), 504-506
- Making a Chemical Rainbow
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  Journal of Chemical Education2010 87 (5), 504-506
  In this laboratory experiment, high school students are challenged to prepare a six-layered chemical “rainbow” in a test tube. Students start with six unknown, colorless liquids and six pigments ranging from violet to red. The experiment is problem based ...
  Abstract | Full Text HTML | Hi-Res PDF | PDF w/ Links
Teaching Organic Synthesis: A Comparative Case Study Approach
David A. Vosburg
Journal of Chemical Education2008 85 (11), 1519
- Teaching Organic Synthesis: A Comparative Case Study Approach
  David A. Vosburg
  Journal of Chemical Education2008 85 (11), 1519
  In this course, students encounter reactions and mechanisms in the context of landmark syntheses of biologically important molecules. Students closely examine pairs of syntheses of related or identical molecules to facilitate their appreciation for ...
  Abstract | Hi-Res PDF | PDF w/ Links
Novel Organic Courses
Arietta W. Clauss
Journal of Chemical Education2008 85 (11), 1523
- Novel Organic Courses
  Arietta W. Clauss
  Journal of Chemical Education2008 85 (11), 1523
  JCE offers a wealth of materials for teaching and learning chemistry. This memo identifies some additional resources for teaching organic chemistry available through JCE.
  Abstract | Hi-Res PDF | PDF w/ Links