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The Incorporation of a Single-Crystal X-ray Diffraction Experiment into the Undergraduate Physical Chemistry Laboratory
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Abstract
Recent advances in detector technology and computing methods have made it possible to incorporate X-ray diffraction methods for routine analysis into the undergraduate chemistry curriculum. At the W. M. Keck Foundation Center for Molecular Structure (CMolS) at CSU Fullerton, we have integrated a two-week laboratory for determining crystal structures of organic molecules into the upper-level physical chemistry laboratory course. During this two-week experiment, students prepare a single-crystal sample of an organic substance, collect and integrate diffraction data, then refine a direct-methods structure solution. The laboratory successfully introduces the elementary concepts of X-ray diffraction and crystal structure determination. The refinement results serve as an excellent segue to discussions on the physical properties of crystals, packing interactions, thermal motions, and chirality, which can be expanded into an undergraduate course on X-ray crystallography.
Keywords (Audience):
Upper-Division UndergraduateKeywords (Domain):
Laboratory InstructionKeywords (Pedagogy):
Hands-On Learning / ManipulativesKeywords (Subject):
Crystals / CrystallographyCiting Articles
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).
Bruker SMART X2S Benchtop System: A Means To Making X-ray Crystallography More Mainstream in the Undergraduate Laboratory
Ilia A. Guzei, Nicholas J. Hill, and Uzma I. ZakaiJournal of Chemical Education2010 87 (11), 1257-1259Bruker SMART X2S Benchtop System: A Means To Making X-ray Crystallography More Mainstream in the Undergraduate Laboratory
Ilia A. Guzei, Nicholas J. Hill, and Uzma I. ZakaiJournal of Chemical Education2010 87 (11), 1257-1259Bruker SMART X2S is a portable benchtop diffractometer that requires only a 110 V outlet to operate. The instrument operation is intuitive and facile with an automation layer governing the workflow from behind the scenes. The user participation is ...
The Incorporation of Single Crystal X-ray Diffraction into the Undergraduate Chemistry Curriculum Using Internet-Facilitated Remote Diffractometer Control
P. S. Szalay , M. Zeller and A. D. HunterJournal of Chemical Education2005 82 (10), 1555The Incorporation of Single Crystal X-ray Diffraction into the Undergraduate Chemistry Curriculum Using Internet-Facilitated Remote Diffractometer Control
P. S. Szalay , M. Zeller and A. D. HunterJournal of Chemical Education2005 82 (10), 1555A laboratory experiment on single crystal X-ray diffraction has been developed and implemented in an inorganic chemistry course for undergraduate students via Internet-facilitated remote diffractometer control. The experiment was carried out from a remote ...
Crystallographic Study of Manganese(III) Acetylacetonate: An Advanced Undergraduate Project with Unexpected Challenges
Silvano Geremia and Nicola DemitriJournal of Chemical Education2005 82 (3), 460Crystallographic Study of Manganese(III) Acetylacetonate: An Advanced Undergraduate Project with Unexpected Challenges
Silvano Geremia and Nicola DemitriJournal of Chemical Education2005 82 (3), 460An advanced undergraduate crystallographic experiment is proposed that integrates the well-tested protocol for synthesis of manganese acetylacetonate, Mn(acac)3, with a new low-temperature characterization of the crystal structure of the synthesized ...
Integrating Single Crystal X-Ray Diffraction in the Undergraduate Curriculum
Patrick E. HoggardJournal of Chemical Education2002 79 (4), 420Integrating Single Crystal X-Ray Diffraction in the Undergraduate Curriculum
Patrick E. HoggardJournal of Chemical Education2002 79 (4), 420Aspects of single crystal X-ray crystallography have been introduced into all four years of the chemistry curriculum at Santa Clara University. The laboratory components consist of (a) the determination of a molecular structure from a data set in year one,...
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- Received: August 03, 2009
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