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Grignard Reactions in "Wet" Ether

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David H. Smith

Department of Chemistry, Doane College, Crete, NE 68333-2496

J. Chem. Educ., 1999, 76 (10), p 1427

DOI: 10.1021/ed076p1427

Publication Date (Web): October 1, 1999

Abstract

A small laboratory ultrasonic bath can be used to initiate the Grignard reaction of alkyl or aryl bromides in regular laboratory-quality, undried, diethyl ether and in simple undried test tubes. The reaction typically starts within 30 to 45 seconds and is self-sustaining. Yields and products are the same as obtained with carefully dried ether and equipment. We normally run this reaction at the 1.5-gram scale, but the procedure can be scaled up to at least 10 g of the bromide.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Laboratory Instruction

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Synthesis

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This article has been cited by 1 ACS Journal articles (1 most recent appear below).

Using a Premade Grignard Reagent To Synthesize Tertiary Alcohols in a Convenient Investigative Organic Laboratory Experiment
Roy D. Pointer , Michael A. G. Berg
Journal of Chemical Education2007 84 (3), 483
- Using a Premade Grignard Reagent To Synthesize Tertiary Alcohols in a Convenient Investigative Organic Laboratory Experiment
  Roy D. Pointer , Michael A. G. Berg
  Journal of Chemical Education2007 84 (3), 483
  A commercially available Grignard reagent (3.0 M solution of phenyl magnesium bromide in ether) was used in a convenient Grignard synthesis in a second-year organic chemistry laboratory without any of the typical failures associated with the Grignard ...
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