Prev. Article Next Article Table of Contents

Article

Determination of Thermodynamic Parameters of the Cyclodextrin Inclusion Processes: An Undergraduate Physical Chemistry Lab Experiment

Supporting Info

Your current credentials do not allow retrieval of the full text.

Purchase the full-text

PDF/HTML,
figures/images,
references and tables,
(where available)

M. Valero , L. J. Rodriguez and M. Mercedes Velázquez

Universidad de Salamanca, Departmento de Química Física, Facultad de Farmacia, Apdo. 449, 37080 Salamanca, SPAIN

J. Chem. Educ., 1999, 76 (3), p 418

DOI: 10.1021/ed076p418

Publication Date (Web): March 1, 1999

Section:

History, Education, and Documentation

Abstract

In this lab experiment we describe an investigation of the thermodynamics of the formation of cyclodextrin inclusion complexes by using fluorescence spectroscopy. A naphthalene derivative, 4-(6-methoxy-2-naphthyl)-2 butanone (nabumetone), was used as a guest and two different cyclodextrins, β-cyclodextrin (β-CD) and hydroxypropyl β-cyclodextrin, (HP β-CD), were used as hosts. The thermodynamic parameters of the inclusion process were determined from the temperature dependence of the association constant by using the van't Hoff relation. The results show two different behaviors depending on the nature of the host molecule. These behaviors can be discussed in terms of the nature of driving forces responsible for the interaction. The experiment is designed for physical chemistry laboratory students, although it could also be used in a high-level physical pharmacy course.