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A Facile Oxidation of Alcohols Using Pyridinium Chlorochromate/Silica Gel
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Abstract
An efficient and convenient adaptation of the pyridinium chlorochromate (PCC) oxidation for an organic chemistry student exercise is based on the employment of reagent-grade silica gel, which simplifies workup and purification of the product. The procedures include the oxidation of 4-tert-butylcyclohexanol to 4-tert-butylcyclohexanone and d,l-menthol to d,l-menthone.
Keywords (Audience):
Upper-Division UndergraduateKeywords (Domain):
Laboratory InstructionKeywords (Pedagogy):
Hands-On Learning / ManipulativesKeywords (Subject):
Drugs / PharmaceuticalsCiting Articles
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This article has been cited by 7 ACS Journal articles (5 most recent appear below).
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Christine F. Roberts and Richard C. HartleyThe Journal of Organic Chemistry2004 69 (18), 6145-6148Titanium(IV) benzylidenes (Schrock carbenes) bearing a masked sulfur nucleophile in the ortho position were generated from thioacetals with use of low-valent titanocene complex Cp2Ti[P(OEt)3]2 and alkylidenated Merrifield resin-bound esters to give enol ...
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- Received: August 03, 2009
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