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Developing New Antibiotics with Combinatorial Biosynthesis
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Abstract
Polyketide synthases (PKSs), a class of enzymes found in soil bacteria that produce antibiotics such as erythromycin, string together acetate units using basic organic reactions. The manipulation of the sequence of these reactions at the genetic level has resulted in an alteration of the corresponding chemical structure of the antibiotic produced by the bacteria. This process, called combinatorial biosynthesis, allows the generation of many presently unknown complex structures that can be tested for antibacterial activity, thereby contributing to the race against antibiotic-resistant infectious bacteria.
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This article has been cited by 4 ACS Journal articles (4 most recent appear below).
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Automated Combinatorial Chemistry in the Organic Chemistry Majors Laboratory
Christopher J. Nichols, Larry F. HanneJournal of Chemical Education2010 87 (1), 87-90Automated Combinatorial Chemistry in the Organic Chemistry Majors Laboratory
Christopher J. Nichols, Larry F. HanneJournal of Chemical Education2010 87 (1), 87-90A multidisciplinary experiment has been developed in which students each synthesize a combinatorial library of 48 hydrazones with the aid of a liquid-handling robot. Each product is then subjected to a Kirby−Bauer disk diffusion assay to assess its ...
Combinatorial Partial Hydrogenation Reactions of 4-Nitroacetophenone. An Undergraduate Organic Laboratory
Kevin W. Kittredge , Susan S. Marine and Richard T. TaylorJournal of Chemical Education2004 81 (10), 1494Combinatorial Partial Hydrogenation Reactions of 4-Nitroacetophenone. An Undergraduate Organic Laboratory
Kevin W. Kittredge , Susan S. Marine and Richard T. TaylorJournal of Chemical Education2004 81 (10), 1494A combinatorial organic chemistry experiment that utilizes an inexpensive commercially available parallel reactor, Argonaut's FirstMate, is described. Students perform a metal catalyzed partial hydrogenation reaction on a multi-functionalized substrate ...
Synthesis of Chemiluminescent Esters: A Combinatorial Synthesis Experiment for Organic Chemistry Students
Robert Duarte , Janne T. Nielsen and Veljko DragojlovicJournal of Chemical Education2004 81 (7), 1010Synthesis of Chemiluminescent Esters: A Combinatorial Synthesis Experiment for Organic Chemistry Students
Robert Duarte , Janne T. Nielsen and Veljko DragojlovicJournal of Chemical Education2004 81 (7), 1010In this laboratory exercise, a peroxyoxalate chemiluminescence experiment has been integrated with a combinatorial synthesis experiment. Students prepare a number of esters, in reactions between acyl chlorides and phenols, and test the compounds for ...
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- Received: August 03, 2009
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