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A Molecular Modeling Program for Teaching Structural Biochemistry
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Abstract
The use of a molecular modeling program to teach structural biochemistry is described. Using the computer program HyperChem, biochemistry majors in a junior-level course make and analyze isomeric cyclopentanes and natural products and study drugs and other small molecules bound to proteins and DNA. The flexibility of the program and the availability of a large number of structures through the files of the Protein Data Bank, PDB, make it possible to study many different molecules and to individualize the assignment for each student in the class. The approach not only enhances learning structural biochemistry but also helps to hold student interest in learning difficult concepts in physical chemistry presented in the lecture part of the course. In this report we outline the seven homework assignments, describe the computer facilities and support personnel needed, and comment on grading procedures used in the course. In addition to being useful in a biochemistry program, the outlined exercises may also provide a way for covering basic biochemical principles in a chemistry curriculum.
Keywords (Audience):
Upper-Division UndergraduateKeywords (Domain):
BiochemistryKeywords (Feature):
Computer Bulletin BoardKeywords (Pedagogy):
Computer-Based LearningKeywords (Subject):
Biophysical ChemistryCiting Articles
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This article has been cited by 3 ACS Journal articles (3 most recent appear below).
[Pi] π Backbonding in Carbonyl Complexes and Carbon–Oxygen Stretching Frequencies: A Molecular Modeling Exercise
Craig D. MontgomeryJournal of Chemical Education2007 84 (1), 102[Pi] π Backbonding in Carbonyl Complexes and Carbon–Oxygen Stretching Frequencies: A Molecular Modeling Exercise
Craig D. MontgomeryJournal of Chemical Education2007 84 (1), 102An exercise in molecular modeling, suitable for a third- or fourth-year course in organometallic or inorganic chemistry, is presented in which the effects of the metal center, the metal charge, and the electron-withdrawing properties of co-ligands upon ...
Mentoring an Undergraduate Research Student in the Structural and Nonstructural Properties of Drugs
Julie B. Ealy and Veronica KvartaJournal of Chemical Education2006 83 (12), 1779Mentoring an Undergraduate Research Student in the Structural and Nonstructural Properties of Drugs
Julie B. Ealy and Veronica KvartaJournal of Chemical Education2006 83 (12), 1779Research at a small campus of a university can be challenging with undergraduate science majors who have only completed one year of biology and chemistry and who leave the campus after their second year. There are time issues in regards to both the ...
Molecular Modeling in the Undergraduate Chemistry Curriculum
Martin B. JonesJournal of Chemical Education2001 78 (7), 867Molecular Modeling in the Undergraduate Chemistry Curriculum
Martin B. JonesJournal of Chemical Education2001 78 (7), 867This article discusses curriculum-wide enhancements in chemistry courses at Adams State College that have resulted from incorporation of computer-based molecular modeling experiments. The courses affected include Introductory Chemistry, General Chemistry, ...
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- Received: August 03, 2009
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