An Unexpected Event When Chymotrypsin Performs Its Physiological Role

Ivan G. Darvey
Department of Biochemistry, The University of Sydney, Sydney, NSW 2006, Australia
J. Chem. Educ., 2000, 77 (3), p 422
DOI: 10.1021/ed077p422
Publication Date (Web): March 1, 2000
History, Education, and Documentation

Abstract

One of the events that occur during the chymotrypsin-catalyzed hydrolysis of proteins is an example of an exception to a rule of thumb taught in introductory organic chemistry courses, namely, that amides can't readily be converted to esters. If biochemistry teachers and the authors of textbooks of biochemistry commented on this unusual reaction, it would emphasize further the remarkable part chymotrypsin plays as a catalyst in carrying out its main perceived "physiological role".

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Biochemistry

Keywords (Pedagogy):

Misconceptions / Discrepant Events

Keywords (Subject):

Catalysis
View: Hi-Res PDF | PDF w/ Links

Tools

SciFinder Links

SciFinder subscribers: Click to sign in | Not a SciFinder subscriber? Learn more at www.cas.org

Explore by:

History

  • Received: August 03, 2009

Recommend & Share

  • Share on ACS NetworkACS Network
  • Add to FacebookFacebook
  • Tweet ThisTweet This
  • Add to CiteULikeCiteULike
  • Add to NewsvineNewsvine
  • Digg ThisDigg This
  • Add to DeliciousDelicious

Related Content