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Tablet Analysis Using Gravimetric Dilutions

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Larry A. Simonson

Department of Chemistry and Food Science, Framingham State College, Framingham, MA 01701-9101

J. Chem. Educ., 2001, 78 (10), p 1387

DOI: 10.1021/ed078p1387

Publication Date (Web): October 1, 2001

Section:

History, Education, and Documentation

Abstract

This experiment introduces the concept of gravimetric dilutions in the context of tablet analysis. Caffeine tablets are analyzed by absorbance at 274 nm with reference to a standard calibration graph and tested for compliance with the USP criterion. All samples and standards are prepared using gravimetric dilutions without reference to volume or density. This experiment is appropriate for high school and college freshman chemistry courses and may be useful at higher levels. It is only necessary that students have had exposure to Beer's law.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Analytical Chemistry

Keywords (Pedagogy):

Hands-On Learning / Manipulatives

Keywords (Subject):

Drugs / Pharmaceuticals

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