Anticancer Activity of Estradiol Derivatives: A Quantitative Structure-Activity Relationship Approach

Ken Muranaka
K''s Garden Nishioji, Kyoto, Japan
J. Chem. Educ., 2001, 78 (10), p 1390
DOI: 10.1021/ed078p1390
Publication Date (Web): October 1, 2001
History, Education, and Documentation

Abstract

Commercial packages to implement modern QSAR (quantitative structure-activity relationship) techniques are highly priced; however, the essence of QSAR can be taught without them. Microsoft Excel was used to analyze published data on anticancer activities of estradiol analogs by a QSAR approach. The resulting QSAR equations highly correlate the structural features and physicochemical properties of the analogs with the observed biological activities by multiple linear regression.

Keywords (Audience):

Upper-Division Undergraduate

Keywords (Domain):

Chemoinformatics

Keywords (Pedagogy):

Computer-Based Learning

Keywords (Subject):

Drugs / Pharmaceuticals
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  • Received: August 03, 2009

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