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An Indexed Combinatorial Library: The Synthesis and Testing of Insect Repellents

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William H. Miles , Kathy A. Gelato , Kristen M. Pompizzi , Aislinn M. Scarbinsky and Brian K. Albrecht

Department of Chemistry, Lafayette College, Easton, PA 18042

Elaine R. Reynolds

Department of Biology, Lafayette College, Easton, PA 18042

J. Chem. Educ., 2001, 78 (4), p 540

DOI: 10.1021/ed078p540

Publication Date (Web): April 1, 2001

Section:

History, Education, and Documentation

Abstract

An indexed combinatorial library of amides was prepared by the reaction of amines and acid chlorides. A simple test for insect repellency using fruit flies (Drosophila melanogaster) allowed the determination of the most repellent sublibraries. The student-generated data were collected and analyzed to determine the most active amide(s) in the library. This experiment illustrates the fundamentals of combinatorial chemistry, a field that has undergone explosive growth in the last decade.

Keywords (Audience):

Second-Year Undergraduate

Keywords (Domain):

Laboratory Instruction

Keywords (Pedagogy):

Collaborative / Cooperative Learning

Keywords (Subject):

Drugs / Pharmaceuticals

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